2026
Mechanical insights into regulation of bio–nano interactions for lipid-based nanocarriersYang F, Wang Y, Lu Y, Lin L, Wang Y, Sun X, Liu M, Chiappini C, Wang Y-F, Liang X-J
Discover Nano · 2026 · vol. 21, no. 1 · Open access version
Nano-enabled living materials and living electronics: a roadmap for innovation and impactTian B, Sha B, Jiang Y, Nandakumar A, Ezerins A, Kim SS, Cohen-Karni T, Jiao Y, Zhang A, Wang Y, Guo Y, …, Minev IR
Nano Futures · 2026 · vol. 10, no. 2, pp. 022001
Perfusion microbioreactor for CAR-Treg manufacturingEdwards W, Sun N, Wang Y, Lu Y, Wang C, Mastronicola D, Scottà C, Romano M, Cejas CM, Espinet A, Lombardi G, Chiappini C
iScience · 2026 · vol. 29, no. 4, pp. 115246
Caveolar Endocytosis Governs Nanoneedle TransfectionSun N, Wang C, Wang Y, Edwards W, Dimitrievska M, Li Y, Vasovic N, McLennan S, Zhu H, Mäkilä E, Salonen J, …, Chiappini C
ACS Nano · 2026 · vol. 20, no. 6, pp. 4663–4676 · Open access version
2025
Nanoneedles enable spatiotemporal lipidomics of living tissuesGu C, Martella DA, Rose LA, Rouatbi N, Wang C, Zam A, Caprettini V, Jensen M, Liu S, Hagemann C, Memdouh S, …, Chiappini C
Nature Nanotechnology · 2025 · Open access version
Nanoneedle-Based Electroporation for Efficient Manufacturing of Human Primary Chimeric Antigen Receptor Regulatory T-CellsSun N, Wang C, Edwards W, Wang Y, Lu X, Gu C, McLennan S, Shangaris P, Qi P, Mastronicola D, Scottà C, …, Chiappini C
Advanced Science · 2025 · vol. 12, no. 21, pp. 2416066 · Open access version
Porous Silicon Nanoneedles Efficiently Deliver Adenine Base Editor to Correct a Recurrent Pathogenic COL7A1 Variant in Recessive Dystrophic Epidermolysis BullosaMustfa SA, Dimitrievska M, Wang C, Gu C, Sun N, Romańczuk K, Karpinski P, Łaczmański Ł, McGrath JA, Jacków-Malinowska J, Chiappini C
Advanced Materials · 2025 · vol. 37, pp. e2414728
2024
NoButter: An R package for reducing transcript dispersion in CosMx Spatial Molecular Imaging DataO’Hora B, Laddach R, Nuamah R, Alberts E, Wall I, Bell J, Johnston DA, James S, Norman J, Jones MG, Chiappini C, …, Quist J
PreprintbioRxiv (Cold Spring Harbor Laboratory) · 2024
Spatially-Resolved Organoid Transfection by Porous Silicon-Mediated OptoporationSpiteri C, Caprettini V, Wang Y, Dominguez-Gil S, Kaasalainen M, Wang C, Martella DA, McLennan S, Vashisth P, Gary-Bobo M, Nguyen C, …, Chiappini C
Advanced Materials · 2024 · vol. 36, no. 49, pp. 2407650 · Open access version
Integrating Porous Silicon Nanoneedles within Medical Devices for Nucleic Acid NanoinjectionWang C, Gu C, Popp C, Vashisth P, Mustfa SA, Martella DA, Spiteri C, McLennan S, Sun N, Riddle M, Eide CR, …, Chiappini C
ACS Nano · 2024 · vol. 18, no. 23, pp. 14938–14953
Opto-Lipidomics of TissuesJensen M, Liu S, Stepula E, Martella DA, Birjandi AA, Farrell-Dillon K, Chan KLA, Parsons M, Chiappini C, Chapple SJ, Mann GE, …, Bergholt MS
Advanced Science · 2024 · vol. 11, no. 14, pp. 2302962 · Open access version
Lithiated porous silicon nanowires stimulate periodontal regenerationKaasalainen M, Zhang R, Vashisth P, Birjandi AA, S’Ari M, Martella DA, Isaacs M, Mäkilä E, Wang C, Moldenhauer E, Clarke P, …, Chiappini C
Nature Communications · 2024 · vol. 15, no. 1 · Open access version
2023
Two-Photon Light Trigger siRNA Transfection of Cancer Cells Using Non-Toxic Porous Silicon NanoparticlesChaix A, Cueto-Diaz E, Dominguez-Gil S, Spiteri C, Lichon L, Maynadier M, Dumail X, Aggad D, Delalande A, Bessière A, Pichon C, …, Cunin F
Advanced Healthcare Materials · 2023 · vol. 12, no. 27, pp. 2301052 · Open access version
A method for reproducible high-resolution imaging of 3D cancer cell spheroidsPhillips TA, Caprettini V, Aggarwal N, Marcotti S, Tetley R, Mao Y, Shaw T, Chiappini C, Parsons M, Cox S
Journal of Microscopy · 2023 · vol. 291, no. 1, pp. 30–42 · Open access version
2022
Biointerface design for vertical nanoprobesElnathan R, Barbato MG, Guo X, Mariano A, Wang Z, Santoro F, Shi P, Voelcker NH, Xie X, Young JL, Zhao Y, …, Chiappini C
Nature Reviews Materials · 2022 · vol. 7, no. 12, pp. 953–973 · Open access version
2021
Tutorial: using nanoneedles for intracellular deliveryChiappini C, Chen Y, Aslanoglou S, Mariano A, Mollo V, Mu H, De Rosa E, He G, Tasciotti E, Xie X, Santoro F, …, Elnathan R
Nature Protocols · 2021 · vol. 16, no. 10, pp. 4539–4563 · Open access version
Multiplexing physical stimulation on single human induced pluripotent stem cell-derived cardiomyocytes for phenotype modulationKit-Anan W, Mazo MM, Wang BX, Leonardo V, Pence IJ, Gopal S, Gelmi A, Nagelkerke A, Becce M, Chiappini C, Harding SE, …, Stevens MM
Biofabrication · 2021 · vol. 13, no. 2 · Open access version
2019
Immunogold FIB-SEM: Combining Volumetric Ultrastructure Visualization with 3D Biomolecular Analysis to Dissect Cell–Environment InteractionsGopal S, Chiappini C, Armstrong JPK, Chen Q, Serio A, Hsu C-C, Meinert C, Klein TJ, Hutmacher DW, Rothery S, Stevens MM
Advanced Materials · 2019 · vol. 31, no. 32 · Open access version
Nanoneedle-Mediated Stimulation of Cell Mechanotransduction MachineryHansel CS, Crowder SW, Cooper S, Gopal S, Da Cruz MJP, Martins LDO, Keller D, Rothery S, Becce M, Cass AEG, Bakal C, …, Stevens MM
ACS Nano · 2019 · vol. 13, no. 3, pp. 2913–2926
2018
Correlated heterospectral lipidomics for biomolecular profiling of remyelination in multiple sclerosisBergholt MS, Serio A, McKenzie JS, Boyd A, Soares RF, Tillner J, Chiappini C, Wu V, Dannhorn A, Takats Z, Williams A, Stevens MM
ACS Central Science · 2018 · vol. 4, no. 1, pp. 39–51 · Open access version
MACE silicon nanostructuresChiappini C
Book chapterHandbook of Porous Silicon: Second Edition · 2018 · vol. 1-2, pp. 247–267 · 2nd edition
2016
Angular Approach Scanning Ion Conductance MicroscopyShevchuk A, Tokar S, Gopal S, Sanchez-Alonso JL, Tarasov AI, Vélez-Ortega AC, Chiappini C, Rorsman P, Stevens MM, Gorelik J, Frolenkov GI, …, Korchev YE
Biophysical Journal · 2016 · vol. 110, no. 10, pp. 2252–2265 · Open access version
Spearhead Nanometric Field-Effect Transistor Sensors for Single-Cell AnalysisZhang Y, Clausmeyer J, Babakinejad B, Córdoba AL, Ali T, Shevchuk A, Takahashi Y, Novak P, Edwards C, Lab M, Gopal S, …, Korchev YE
ACS Nano · 2016 · vol. 10, no. 3, pp. 3214–3221 · Open access version
2015
Gold-silica quantum rattles for multimodal imaging and therapyHembury M, Chiappini C, Bertazzo S, Kalber TL, Drisko GL, Ogunlade O, Walker-Samuel S, Krishna KS, Jumeaux C, Beard P, Kumar CSSR, …, Langer R
Proceedings of the National Academy of Sciences of the United States of America · 2015 · vol. 112, no. 7, pp. 1959–1964 · Open access version
2013
Silicon Micro- and Nanofabrication for MedicineFine D, Grattoni A, Goodall R, Bansal SS, Chiappini C, Hosali S, Van De Ven AL, Srinivasan S, Liu X, Godin B, Brousseau L, …, Ferrari M
Advanced Healthcare Materials · 2013 · vol. 2, no. 5, pp. 632–666 · Open access version
Synthetic nanoparticles functionalized with biomimetic leukocyte membranes possess cell-like functionsParodi A, Quattrocchi N, Van De Ven AL, Chiappini C, Evangelopoulos M, Martinez JO, Brown BS, Khaled SZ, Yazdi IK, Enzo MV, Isenhart L, …, Tasciotti E
Nature Nanotechnology · 2013 · vol. 8, no. 1, pp. 61–68 · Open access version
2010
Logic-embedded vectors for intracellular partitioning, endosomal escape, and exocytosis of nanoparticlesSerda RE, MacK A, Van De Ven AL, Ferrati S, Jr. KD, Godin B, Chiappini C, Landry M, Brousseau L, Liu X, Bean AJ, Ferrari M
Small · 2010 · vol. 6, no. 23, pp. 2691–2700 · Open access version
In vivo evaluation of safety of nanoporous silicon carriers following single and multiple dose intravenous administrations in miceTanaka T, Godin B, Bhavane R, Nieves-Alicea R, Gu J, Liu X, Chiappini C, Fakhoury JR, Amra S, Ewing A, Li Q, …, Ferrari M
International Journal of Pharmaceutics · 2010 · vol. 402, no. 1-2, pp. 190–197 · Open access version
Cellular association and assembly of a multistage delivery systemSerda RE, MacK A, Pulikkathara M, Zaske AM, Chiappini C, Fakhoury JR, Webb D, Godin B, Conyers JL, Liu X, Bankson JA, Ferrari M
Small · 2010 · vol. 6, no. 12, pp. 1329–1340 · Open access version
Sustained small interfering RNA delivery by mesoporous silicon particlesTanaka T, Mangala LS, Vivas-Mejia PE, Nieves-Alicea R, Mann AP, Mora E, Han H-D, Shahzad MMK, Liu X, Bhavane R, Gu J, …, Ferrari M
Cancer Research · 2010 · vol. 70, no. 9, pp. 3687–3696 · Open access version
Tailoring the degradation kinetics of mesoporous silicon structures through PEGylationGodin B, Gu J, Serda RE, Bhavane R, Tasciotti E, Chiappini C, Liu X, Tanaka T, Decuzzi P, Ferrari M
Journal of Biomedical Materials Research - Part A · 2010 · vol. 94, no. 4, pp. 1236–1243 · Open access version
Tailored porous silicon microparticles: Fabrication and propertiesChiappini C, Tasciotti E, Fakhoury JR, Fine D, Pullan L, Wang Y-C, Fu L, Liu X, Ferrari M
ChemPhysChem · 2010 · vol. 11, no. 5, pp. 1029–1035 · Open access version
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