Light-guided gene delivery into organoids
In Advanced Materials, porous silicon nanoparticles and laser pulses deliver nucleic acids into chosen regions of 3D organoid cultures.
Controlling where genes are delivered inside 3D tissue models is hard. Chantelle Spiteri, Valeria Caprettini, Yikai Wang and colleagues show that bioresorbable porous silicon nanoparticles act as a safe photosensitiser for optoporation, enabling spatially-resolved transfection of organoids.
Spiteri C, Caprettini V, Wang Y, … Chiappini C. Advanced Materials (2024). doi:10.1002/adma.202407650